| Pen. | FC Juarez | 1-1(1-1) | Club Universidad Nacional* | ||
| FT | Monterrey | 1-2 (0-0) | Pachuca |
| FT | Deportivo Pereira | 1-0 (1-0) | Junior FC | ||
| FT | Santa Fe | 0-0 (0-0) | Chico FC | ||
| FT | Fortaleza FC | 0-0 (0-0) | Independiente Medellin | ||
| FT | America de Cali | 2-0 (0-0) | Deportivo Cali | ||
| FT | Bucaramanga | 0-2 (0-1) | Millonarios |
| FT | Houston Dynamo FC | 2-0 (0-0) | Austin FC | ||
| FT | Nashville SC | 7-2 (5-0) | Chicago Fire FC | ||
| FT | Colorado Rapids | 1-1 (0-1) | Seattle Sounders FC | ||
| FT | Minnesota United | 1-3 (0-0) | Vancouver Whitecaps | ||
| FT | Inter Miami CF | 3-4 (2-1) | FC Dallas | ||
| FT | Los Angeles FC | 2-2 (0-0) | St. Louis City | ||
| FT | LA Galaxy | 2-4 (0-1) | Portland Timbers |
| FT | River Plate | 2-1 (2-1) | Boca Juniors | ||
| FT | Instituto | 1-1 (0-0) | Sarmiento | ||
| FT | Lanus | 1-0 (0-0) | San Martin San Juan | ||
| FT | Independiente | 0-0 (0-0) | Deportivo Riestra |
| FT | Botafogo RJ | 2-0 (1-0) | Fluminense | ||
| FT | Flamengo | 4-0 (3-0) | Corinthians | ||
| FT | Cruzeiro | 1-0 (0-0) | Vasco da Gama | ||
| FT | Palmeiras | 0-1 (0-0) | Bahia | ||
| FT | Vitoria | 1-1 (0-1) | Gremio | ||
| FT | Santos FC | 1-2 (0-0) | Red Bull Bragantino |
| FT | Luqueno | 0-0 (0-0) | General Caballero JLM | ||
| FT | Sportivo Ameliano | 0-0 (0-0) | Libertad |
| FT | CSD Macara | 0-1 (0-0) | Barcelona SC | ||
| FT | Aucas | 2-0 (1-0) | Mushuc Runa | ||
| FT | Orense | 1-2 (1-0) | Independiente del Valle | ||
| FT | Emelec | 0-1 (0-1) | Tecnico Universitario |
| FT | O'Higgins | 2-2 (2-0) | Deportes Iquique | ||
| FT | Palestino | 2-3 (0-1) | Universidad de Chile | ||
| FT | Huachipato | 2-1 (2-1) | Union Espanola |
| FT | Moreirense | 1-1 (0-0) | Nacional | ||
| FT | Benfica | 6-0 (4-0) | AVS Futebol SAD | ||
| FT | Vitoria de Guimaraes | 3-0 (3-0) | Rio Ave | ||
| FT | Boavista | 0-5 (0-2) | Sporting CP |
| FT | Vestri | 0-1 (0-0) | Breidablik | ||
| FT | KA Akureyri | 3-2 (1-1) | FH Hafnarfjordur | ||
| FT | KR Reykjavik | 5-0 (2-0) | IA Akranes |
| FT | Racing Santander | 2-1 (2-0) | Deportivo La Coruna | ||
| FT | Malaga | 1-0 (1-0) | Castellon | ||
| FT | Tenerife | 1-1 (0-1) | Eibar | ||
| FT | Saragosse | 1-1 (0-0) | SD Huesca |
| FT | Como | 1-0 (0-0) | Genoa | ||
| FT | Venezia | 0-2 (0-1) | AC Milan | ||
| FT | Fiorentina | 2-1 (2-0) | Empoli | ||
| FT | Inter Milan | 0-1 (0-1) | Roma | ||
| FT | Juventus | 2-0 (2-0) | Monza | ||
| FT | Atalanta | 1-1 (0-1) | Lecce | ||
| FT | Naples | 2-0 (2-0) | Torino |
| FT | Angers | 0-2 (0-1) | Lille | ||
| FT | Lens | 0-4 (0-3) | Auxerre | ||
| FT | Montpellier | 0-0 (0-0) | Reims | ||
| FT | Nantes | 0-0 (0-0) | Toulouse | ||
| FT | Marseille | 4-1 (3-1) | Brest |
| FT | FK Crvena Zvezda | 5-2 (3-0) | OFK Beograd | ||
| FT | Partizan Beograd | 3-1 (1-0) | FK Radnicki 1923 | ||
| FT | Vojvodina | 0-3 (0-0) | TSC Backa Topola |
| FT | Rapid Bucuresti | 1-2 (0-2) | FCSB |
| FT | FK Sarajevo | 2-1 (1-0) | Zeljeznicar | ||
| FT | GOSK Gabela | 0-1 (0-1) | FK Velez Mostar | ||
| FT | Zrinjski Mostar | 2-1 (1-0) | Siroki Brijeg |
| FT | Ludogorets Razgrad | 2-0 (1-0) | Cherno More Varna |
| FT | RWD Molenbeek | 3-2 (1-0) | SC Lokeren-Temse | ||
| FT | SK Beveren | 1-2 (0-1) | Patro Eisden |
| FT | Maccabi Netanya | 2-1 (1-1) | Hapoel Beer Sheva |
| FT | Rosenborg | 0-0 (0-0) | Molde | ||
| FT | Bodoe/Glimt | 3-0 (0-0) | KFUM | ||
| FT | Brann | 3-2 (0-2) | Bryne | ||
| FT | FK Haugesund | 0-0 (0-0) | Fredrikstad | ||
| FT | Kristiansund BK | 0-2 (0-0) | Vaalerenga | ||
| FT | Sandefjord | 2-0 (1-0) | Hamarkameratene | ||
| FT | Sarpsborg 08 | 2-3 (0-1) | Stroemsgodset | ||
| FT | Viking | 4-4 (0-1) | Tromsoe |
| FT | AEK Athens | 0-2 (0-1) | Olympiacos | ||
| FT | PAOK Thessaloniki FC | 2-1 (1-1) | Panathinaikos |
| FT | Isloch | 4-0 (1-0) | FK Molodechno | ||
| FT | Torpedo Zhodino | 1-1 (0-0) | Maxline Vitebsk | ||
| FT | Dinamo Minsk | 4-1 (1-1) | FC Minsk |
| FT | Osijek | 2-0 (0-0) | Hajduk Split | ||
| FT | Dinamo Zagreb | 1-0 (1-0) | Rijeka |
| FT | Banik Ostrava | 1-2 (0-2) | Jablonec | ||
| FT | Viktoria Plzen | 2-0 (1-0) | Sparta Prague |
| FT | La Gantoise | 0-1 (0-0) | Anderlecht | ||
| FT | RC Genk | 0-1 (0-1) | Royal Antwerp | ||
| FT | Union St.Gilloise | 0-0 (0-0) | Club Brugge |
| AP | Kawasaki Frontale | AP 3-2 | Al-Sadd |
| FT | Aris Limassol | 1-0 (1-0) | AEK Larnaca |
| FT | AGF | 1-3 (0-1) | FC Koebenhavn | ||
| FT | FC Midtjylland | 5-0 (4-0) | FC Nordsjaelland |
| FT | Zilina | 2-1 (1-1) | Spartak Trnava |
| FT | Skalica | 0-1 (0-1) | Komarno |
| FT | Stellenbosch FC | 0-0 (0-0) | Simba SC | ||
| FT | CS Constantine | 1-0 (0-0) | RSB Berkane |
| FT | Chelsea (F) | 1-4 (0-3) | FC Barcelone (F) | ||
| FT | Lyon (F) | 1-4 (0-2) | Arsenal Women |
| FT | Sabail | 1-1 (0-1) | Araz PFK | ||
| FT | Sabah FK | 1-1 (0-1) | Qarabag FK |
| FT | Konyaspor | 3-1 (0-1) | Adana Demirspor | ||
| FT | Trabzonspor | 4-3 (4-2) | Alanyaspor | ||
| FT | Eyupspor | 1-5 (0-1) | Galatasaray | ||
| FT | Kayserispor | 1-0 (1-0) | Çaykur Rizespor |
| FT | Krylya Sovetov Samara | 2-0 (0-0) | FC Orenburg | ||
| FT | Khimki | 2-2 (2-1) | Akron Togliatti | ||
| FT | Rubin Kazan | 2-1 (0-1) | Fakel |
| FT | MTK Budapest | 2-3 (0-3) | Ferencvarosi TC | ||
| FT | Zalaegerszegi TE | 0-0 (0-0) | Kecskemeti TE |
| FT | Sliema Wanderers | 1-1 (0-0) | Hamrun Spartans | ||
| FT | Birkirkara | 1-1 (1-0) | Marsaxlokk FC | ||
| FT | Floriana | 3-0 (1-0) | Mosta |
| FT | Hibernians | 1-1 (1-0) | Balzan FC |
| FT | Nottingham | 0-2 (0-1) | Manchester City |
| FT | IF Gnistan | 1-2 (1-0) | KuPS | ||
| FT | IFK Mariehamn | 3-2 (2-0) | Ilves |
| FT | VFL Bochum | 1-1 (0-1) | Union Berlin | ||
| FT | Werder Bremen | 0-0 (0-0) | St. Pauli |
| FT | Nafta | 1-5 (0-1) | Koper | ||
| FT | NK Celje | 3-3 (1-1) | Olimpija Ljubljana |
| FT | AFC Bournemouth | 1-1 (1-0) | Manchester United | ||
| FT | Liverpool | 5-1 (3-1) | Tottenham Hotspur |
| FT | Korona Kielce | 3-1 (1-1) | Jagiellonia Bialystok | ||
| FT | Gornik Zabrze | 0-0 (0-0) | Widzew Lodz | ||
| FT | Radomiak Radom | 2-2 (0-2) | Lech Poznan |
| FT | FK Kauno Zalgiris | 0-1 (0-0) | Banga Gargzdai | ||
| FT | Suduva | 4-0 (4-0) | Hegelmann |
| FT | Rapid Vienne | 0-0 (0-0) | BW Linz | ||
| FT | Wolfsberger AC | 2-1 (1-0) | Red Bull Salzbourg | ||
| FT | Sturm Graz | 0-1 (0-0) | Austria Wien |
| FT | Vorskla | 3-0 (1-0) | Veres Rivne | ||
| FT | FC Kolos Kovalivka | 1-1 (0-0) | Polissya Zhytomyr | ||
| FT | Shakhtar Donetsk | 2-2 (2-0) | Dynamo Kyiv |
| FT | Fortuna Sittard | 1-0 (0-0) | Willem II | ||
| FT | Ajax Amsterdam | 1-1 (0-0) | Sparta Rotterdam | ||
| FT | SC Heerenveen | 1-0 (0-0) | NEC Nijmegen | ||
| FT | Almere City FC | 0-0 (0-0) | Go Ahead Eagles |
| FT | Haecken | 1-1 (0-0) | Hammarby | ||
| FT | Mjaellby | 4-1 (3-0) | Degerfors | ||
| FT | AIK | 2-0 (2-0) | Elfsborg | ||
| FT | IFK Vaernamo | 1-3 (0-2) | IFK Norrkoeping | ||
| FT | Sirius | 1-1 (1-1) | Halmstads BK |
| FT | Feirense | 0-1 (0-0) | FC Porto B | ||
| FT | Portimonense | 2-2 (0-1) | Tondela | ||
| FT | Leixoes | 3-1 (0-1) | Penafiel |
| FT | Villarreal | 1-0 (0-0) | Espanyol |
| FT | Faetano | 2-3 (2-0) | FC Fiorentino | ||
| FT | La Fiorita Montegiardino | 2-0 (1-0) | S.S. Murata | ||
| FT | SS Pennarossa | 3-3 (1-2) | Virtus Acquaviva |
| FT | Flora Tallinn | 2-3 (1-1) | Nomme JK Kalju | ||
| FT | FC Kuressaare | 2-1 (1-0) | Narva Trans |
| FT | CS Fola Esch | 0-3 (0-1) | Swift Hesperange | ||
| FT | F91 Dudelange | 1-1 (0-0) | Union Titus Petange | ||
| FT | FC Differdange 03 | 4-0 (2-0) | US Hostert | ||
| FT | FC Rodange 91 | 0-0 (0-0) | FC Victoria Rosport | ||
| FT | FC Wiltz 71 | 3-2 (1-2) | SC Bettembourg | ||
| FT | Racing FC Union Luxembourg | 2-0 (0-0) | AS Jeunesse Esch | ||
| FT | US Mondorf les Bains | 2-1 (0-0) | FC Progres Niederkorn | ||
| FT | Una Strassen | 5-0 (1-0) | FC Mondercange |
| AP | FC Bâle | AP 3-2 | Lausanne |
| FT | Dukagjini | 2-1 (0-1) | Feronikeli |
| FT | Catanzaro | 1-3 (0-2) | Palermo | ||
| FT | Sudtirol | 2-0 (1-0) | Juve Stabia |
| FT | Botev Plovdiv | 1-1 (1-0) | Beroe |
| FT | Lyngby | 2-0 (1-0) | Silkeborg | ||
| FT | Soenderjyske Fodbold | 2-2 (2-0) | Viborg |
| FT | Wuhan Three Towns | 2-1 (0-1) | Tianjin Jinmen Tiger | ||
| FT | Qingdao Hainiu | 1-1 (0-1) | Meizhou Hakka | ||
| FT | Zhejiang Professional | 2-1 (0-0) | Qingdao West Coast |
| FT | FC Gloria Buzau | 0-2 (0-1) | Botosani |
| FT | Dingnan United | 2-2 (0-2) | Guangxi Pingguo | ||
| FT | Shaanxi Union | 0-1 (0-1) | Shijiazhuang Gongfu | ||
| FT | Suzhou Dongwu | 2-0 (0-0) | Shanghai Jiading | ||
| FT | Guangdong GZ-Power | 2-0 (0-0) | Foshan Nanshi |
| FT | Hamburger SV | 1-2 (1-2) | Karlsruher SC | ||
| FT | Hannover 96 | 1-0 (0-0) | FC Koeln | ||
| FT | Kaiserslautern | 2-1 (1-0) | Schalke 04 |
| FT | Teplice | 2-2 (1-2) | Dukla Praha |
| FT | Gimpo FC | 0-1 (0-0) | Jeonnam Dragons | ||
| FT | Suwon Samsung Bluewings | 3-2 (0-0) | Seongnam FC | ||
| FT | Busan I'Park | 3-2 (2-2) | Hwaseong FC |
| FT | Pohang Steelers | 1-0 (1-0) | FC Seoul | ||
| FT | Daejeon Hana Citizen | 1-0 (0-0) | Gangwon FC | ||
| FT | Gimcheon Sangmu | 2-0 (1-0) | Ulsan HD FC |
| FT | Auckland FC | 1-0 (0-0) | Perth Glory | ||
| FT | Western United FC | 1-0 (1-0) | Sydney FC |
