| FT | Tigres | 1-1 (0-0) | Cruz Azul | ||
| FT | Vancouver Whitecaps | 2-0 (1-0) | Inter Miami CF |
| FT | Vitoria | 0-1 (0-0) | Cerro Largo | ||
| FT | Universidad Catolica | 3-1 (1-1) | Defensa y Justicia |
| FT | Caracas | 1-1 (0-1) | Atletico MG | ||
| FT | Deportes Iquique | 2-2 (1-1) | Cienciano |
| FT | Mushuc Runa | 3-0 (1-0) | Union | ||
| FT | Palestino | 2-1 (1-0) | Cruzeiro |
| FT | Bolivar | 2-3 (0-2) | Palmeiras | ||
| FT | Cerro Porteno | 2-2 (2-1) | Sporting Cristal |
| FT | Bahia | 1-0 (0-0) | Atletico Nacional |
| FT | Atletico Grau | 2-2 (1-2) | Luqueno | ||
| FT | Godoy Cruz | 2-2 (0-1) | Gremio |
| FT | Corinthians | 1-0 (0-0) | Racing |
| FT | Central Cordoba de Santiago | 2-1 (2-1) | Deportivo Tachira |
| FT | Leganes | 1-1 (0-0) | Girona | ||
| FT | Osasuna | 1-0 (1-0) | FC Séville | ||
| FT | Atletico Madrid | 3-0 (2-0) | Rayo Vallecano | ||
| FT | Real Betis | 5-1 (1-1) | Real Valladolid |
| FT | IBV Vestmannaeyjar | 3-1 (2-1) | Fram Reykjavik | ||
| FT | Afturelding | 1-0 (0-0) | Vikingur Reykjavik |
| FT | Bologna | 2-1 (1-1) | Empoli |
| FT | AZ Alkmaar | 1-1 (0-0) | NAC Breda | ||
| FT | FC Twente | 1-3 (1-1) | PSV Eindhoven |
| FT | Patro Eisden | 3-2 (2-1) | SK Beveren | ||
| FT | SC Lokeren-Temse | 2-0 (2-0) | RWD Molenbeek |
| FT | Club Brugge | 0-1 (0-1) | Union St.Gilloise |
| FT | Al-Orobah FC | 2-2 (2-0) | Al-Fayha | ||
| FT | Al-Taawoun | 4-3 (3-1) | Al-Raed |
| FT | FC Telavi | 0-0 (0-0) | Iberia 1999 | ||
| FT | FC Gareji 1960 | 0-1 (0-0) | Dila Gori | ||
| FT | Torpedo Kutaisi | 2-1 (1-0) | FC Gagra |
| FT | Djurgaarden | 1-0 (0-0) | Oesters IF | ||
| FT | GAIS | 1-1 (0-1) | Brommapojkarna | ||
| FT | IFK Norrkoeping | 2-3 (2-0) | IFK Göteborg | ||
| FT | IFK Vaernamo | 1-2 (0-1) | AIK |
| FT | Paradou AC | 0-0 (0-0) | ES Setif |
| FT | FK Spartak Subotica | 2-1 (1-0) | Napredak | ||
| FT | Jedinstvo Ub | 4-1 (4-1) | Cukaricki |
| FT | Auda | 2-0 (1-0) | Grobina |
| FT | Bucaramanga | 1-1 (0-1) | Fortaleza |
| FT | Libertad | 0-2 (0-0) | Sao Paulo |
| FT | Independiente del Valle | 2-2 (2-0) | River Plate |
| FT | Estudiantes | 1-0 (1-0) | Botafogo RJ |
