| FT | Toluca | 2-2 (2-2) | Cruz Azul | ||
| FT | Tigres | 2-1 (1-0) | Club Universidad Nacional | ||
| FT | Atlas | 1-1 (1-1) | CD Guadalajara | ||
| FT | Santos Laguna | 0-4 (0-2) | Tijuana | ||
| FT | Atletico de San Luis | 2-1 (0-0) | Pachuca | ||
| FT | Leon | 0-2 (0-1) | Monterrey | ||
| FT | FC Juarez | 0-2 (0-0) | Queretaro FC |
| FT | Everton CD | 1-1 (1-1) | Union La Calera | ||
| FT | O'Higgins | 1-0 (0-0) | Palestino | ||
| FT | CD Nublense | 0-0 (0-0) | Coquimbo Unido |
| FT | Gremio | 1-1 (1-0) | Internacional | ||
| FT | Juventude | 2-2 (2-1) | Mirassol | ||
| FT | Atletico MG | 1-0 (0-0) | Botafogo RJ | ||
| FT | Sao Paulo | 2-1 (2-1) | Santos FC | ||
| FT | Fluminense | 1-1 (1-0) | Vitoria | ||
| FT | Fortaleza | 1-2 (0-1) | Palmeiras | ||
| FT | Red Bull Bragantino | 1-0 (1-0) | Cruzeiro |
| FT | Deportivo Riestra | 0-0 (0-0) | San Lorenzo | ||
| FT | San Martin San Juan | 1-0 (1-0) | Godoy Cruz | ||
| FT | Sarmiento | 0-1 (0-0) | Club Atletico Platense | ||
| FT | Rosario Central | 3-0 (1-0) | Instituto |
| FT | Independiente Medellin | 2-0 (2-0) | Once Caldas | ||
| FT | Envigado | 3-1 (1-1) | Tolima | ||
| FT | Union Magdalena | 1-1 (0-0) | Bucaramanga | ||
| FT | Deportivo Cali | 1-0 (1-0) | Atletico Nacional |
| FT | General Caballero JLM | 0-1 (0-0) | Atletico Tembetary | ||
| FT | Cerro Porteno | 1-0 (1-0) | Sportivo Trinidense |
| FT | Independiente del Valle | 2-0 (2-0) | Manta | ||
| FT | Tecnico Universitario | 1-3 (1-2) | Vinotinto del Ecuador | ||
| FT | Universidad Catolica | 2-0 (1-0) | Orense | ||
| FT | Delfin | 0-0 (0-0) | CSD Macara |
| FT | Alverca | 4-0 (1-0) | Oliveirense | ||
| FT | Maritimo | 2-0 (0-0) | Mafra | ||
| FT | Tondela | 0-1 (0-1) | Vizela |
| FT | Simba SC | 1-0 (1-0) | Stellenbosch FC | ||
| FT | RSB Berkane | 4-0 (2-0) | CS Constantine |
| FT | Cartagena | 2-3 (1-2) | Granada CF | ||
| FT | Cordoba | 0-0 (0-0) | Real Oviedo | ||
| FT | Elche | 2-2 (2-2) | Albacete | ||
| FT | Deportivo La Coruna | 0-0 (0-0) | Tenerife |
| FT | Real Valladolid | 2-3 (0-2) | Osasuna | ||
| FT | Villarreal | 2-2 (1-1) | Real Sociedad | ||
| FT | FC Séville | 1-1 (1-1) | Deportivo Alaves | ||
| FT | Real Madrid | 1-0 (0-0) | Athletic Bilbao |
| FT | Empoli | 2-2 (0-0) | Venezia | ||
| FT | Bologna | 1-0 (0-0) | Inter Milan | ||
| FT | AC Milan | 0-1 (0-0) | Atalanta |
| FT | Lille | 3-1 (2-0) | Auxerre | ||
| FT | Brest | 1-3 (1-2) | Lens | ||
| FT | Nice | 2-1 (1-0) | Angers | ||
| FT | Reims | 1-0 (1-0) | Toulouse | ||
| FT | St-Etienne | 2-1 (1-0) | Lyon |
| FT | Suhareka | 1-2 (1-1) | Drita | ||
| FT | FC Prishtina | 0-0 (0-0) | Ferizaj |
| FT | Augsburg | 0-0 (0-0) | Eintracht Frankfurt | ||
| FT | Borussia Dortmund | 3-2 (3-1) | Borussia Moenchengladbach | ||
| FT | St. Pauli | 1-1 (0-1) | Bayer Leverkusen |
| FT | Maccabi Haifa | 1-0 (1-0) | Maccabi Netanya |
| FT | FCSB | 3-2 (1-0) | CFR 1907 Cluj |
| FT | Anderlecht | 0-0 (0-0) | Royal Antwerp | ||
| FT | RC Genk | 1-2 (0-1) | Union St.Gilloise | ||
| FT | La Gantoise | 0-5 (0-3) | Club Brugge |
| FT | Dinamo Moscow | 3-1 (1-1) | Rubin Kazan | ||
| FT | Fakel | 0-2 (0-1) | FC Rostov | ||
| FT | Zenit St. Petersburg | 1-0 (1-0) | Khimki | ||
| FT | CSKA Moscow | 1-1 (0-0) | Krylya Sovetov Samara |
| FT | DAC 1904 Dunajska Streda | 3-2 (3-0) | FC Kosice |
| FT | Dukla Banska Bystrica | 0-1 (0-0) | Komarno |
| FT | FC Barcelone (F) | 4-1 (1-0) | Chelsea (F) |
| FT | Istanbul Basaksehir | 2-1 (2-1) | Gaziantep FK | ||
| FT | Çaykur Rizespor | 1-0 (0-0) | Eyupspor | ||
| FT | Fenerbahce | 3-3 (1-1) | Kayserispor |
| FT | Fulham | 1-2 (1-0) | Chelsea | ||
| FT | Ipswich Town | 0-4 (0-2) | Arsenal | ||
| FT | Manchester United | 0-1 (0-0) | Wolverhampton Wanderers | ||
| FT | Leicester City | 0-1 (0-0) | Liverpool |
| FT | Banga Gargzdai | 2-1 (1-0) | Dainava Alytus | ||
| FT | Hegelmann | 2-1 (2-1) | Zalgiris Vilnius |
| FT | AaB | 2-3 (0-2) | Soenderjyske Fodbold |
| FT | Sturm Graz | 2-0 (1-0) | BW Linz | ||
| FT | Wolfsberger AC | 5-1 (1-1) | Rapid Vienne | ||
| FT | Austria Wien | 1-3 (1-2) | Red Bull Salzbourg |
| FT | Shamakhi FK | 2-1 (1-1) | FC Kapaz | ||
| FT | Zira | 3-1 (2-0) | Sumqayit |
| FT | Kryvbas | 3-0 (1-0) | Zorya | ||
| FT | Inhulets Petrove | 0-0 (0-0) | LNZ Cherkasy | ||
| FT | Veres Rivne | 2-1 (0-1) | Chornomorets Odesa |
| FT | Brommapojkarna | 3-2 (1-0) | IFK Vaernamo | ||
| FT | Oesters IF | 0-1 (0-0) | AIK | ||
| FT | IFK Göteborg | 2-3 (2-2) | Haecken |
| FT | CSM Politehnica Iasi | 3-0 (2-0) | Botosani |
| FT | St. Johnstone | 0-5 (0-4) | Celtic |
| FT | SK Super Nova | 1-2 (1-1) | RFS |
| FT | Fehervar FC | 1-1 (0-0) | MTK Budapest | ||
| FT | Ferencvarosi TC | 7-0 (3-0) | Nyiregyhaza Spartacus FC |
| FT | Tromsoe | 2-3 (1-0) | Kristiansund BK |
| FT | Changchun Yatai | 0-0 (0-0) | Yunnan Yukun | ||
| FT | Henan FC | 3-1 (0-1) | Qingdao Hainiu | ||
| FT | Qingdao West Coast | 2-0 (0-0) | Dalian Yingbo | ||
| FT | Meizhou Hakka | 3-0 (0-0) | Shenzhen Peng City | ||
| FT | Shanghai Port | 1-3 (1-2) | Chengdu Rongcheng FC | ||
| FT | Tianjin Jinmen Tiger | 2-0 (0-0) | Zhejiang Professional |
| FT | Darmstadt | 3-1 (1-0) | Hannover 96 | ||
| FT | FC Koeln | 3-1 (2-1) | Preussen Muenster | ||
| FT | Karlsruher SC | 1-0 (0-0) | Greuther Fuerth | ||
| FT | Magdeburg | 3-0 (1-0) | Jahn Regensburg | ||
| FT | Ulm | 2-3 (1-0) | Hertha Berlin |
| FT | FC Utrecht | 4-0 (1-0) | Ajax Amsterdam |
| FT | Tai'an Tiankuang | 0-2 (0-1) | Shijiazhuang Gongfu | ||
| Pen. | Chongqing Chunlei | 1-1(1-1) | Guangdong GZ-Power* | ||
| FT | Nantong Haimen Codion | 0-1 (0-0) | Guangxi Pingguo |
| FT | Ansan Greeners | 1-3 (0-3) | Busan I'Park | ||
| FT | Chungnam Asan FC | 0-0 (0-0) | Jeonnam Dragons | ||
| FT | Gyeongnam FC | 2-1 (0-0) | Gimpo FC |
| FT | Jeju SK | 2-0 (1-0) | Pohang Steelers | ||
| FT | Jeonbuk Hyundai Motors FC | 3-1 (3-0) | Daegu FC |
| FT | Fagiano Okayama FC | 1-2 (1-0) | Kashima Antlers | ||
| FT | Nagoya Grampus | 2-1 (1-0) | Sanfrecce Hiroshima | ||
| FT | Shimizu S-Pulse | 3-1 (3-1) | Avispa Fukuoka | ||
| FT | Vissel Kobe | 1-0 (0-0) | Machida Zelvia | ||
| FT | Yokohama FC | 1-1 (1-1) | Gamba Osaka | ||
| FT | Cerezo Osaka | 1-1 (1-1) | FC Tokyo | ||
| FT | Kawasaki Frontale | 0-0 (0-0) | Tokyo Verdy | ||
| FT | Shonan Bellmare | 0-1 (0-0) | Kashiwa Reysol | ||
| FT | Urawa Red Diamonds | 3-1 (1-0) | Yokohama F.Marinos |
| FT | Sydney FC | 3-2 (1-2) | Newcastle Jets | ||
| FT | Central Coast Mariners | 2-2 (2-1) | Macarthur FC |
| FT | Chicago Fire FC | 2-3 (1-2) | FC Cincinnati | ||
| FT | Houston Dynamo FC | 2-2 (1-0) | Colorado Rapids | ||
| FT | Minnesota United | 0-0 (0-0) | FC Dallas | ||
| FT | St. Louis City | 0-0 (0-0) | Vancouver Whitecaps | ||
| FT | Real Salt Lake | 0-1 (0-1) | Toronto FC | ||
| FT | Portland Timbers | 3-3 (2-1) | Los Angeles FC | ||
| FT | San Jose Earthquakes | 3-5 (2-3) | Sporting Kansas City |
