| FT | CF America | 0-0 (0-0) | Cruz Azul | ||
| FT | LA Galaxy | 0-0 (0-0) | Tigres | ||
| FT | Vancouver Whitecaps | 1-1 (0-0) | Club Universidad Nacional | ||
| FT | Los Angeles FC | 1-0 (0-0) | Inter Miami CF |
| FT | Luqueno | 1-2 (1-1) | Gremio | ||
| FT | Atletico Grau | 0-2 (0-1) | Godoy Cruz |
| FT | Atletico Nacional | 3-0 (1-0) | Nacional |
| FT | Corinthians | 1-2 (1-2) | Huracan | ||
| FT | Racing | 1-3 (0-2) | America de Cali |
| FT | Vitoria | 1-1 (0-0) | Universidad Catolica |
| FT | Alianza Lima | 0-1 (0-0) | Libertad | ||
| FT | Talleres | 0-1 (0-0) | Sao Paulo |
| FT | Barcelona SC | 1-0 (1-0) | Independiente del Valle | ||
| FT | Universitario de Deportes | 0-1 (0-1) | River Plate |
| FT | Universidad de Chile | 1-0 (0-0) | Botafogo RJ |
| FT | FBC Melgar | 3-3 (1-2) | Vasco da Gama |
| FT | San Antonio Bulo Bulo | 3-2 (1-0) | Olimpia | ||
| FT | Velez Sarsfield | 2-1 (0-0) | Club Atletico Penarol |
| FT | Atletico Madrid | 0-1 (0-1) | Barcelona |
| FT | Benfica | 3-2 (2-1) | Farense |
| FT | Cannes | 1-2 (0-1) | Reims |
| FT | Atletico Tucuman | 2-1 (0-0) | All Boys |
| FT | AC Milan | 1-1 (0-0) | Inter Milan |
| FT | AFC Bournemouth | 1-2 (0-1) | Ipswich Town | ||
| FT | Brighton & Hove Albion | 0-3 (0-0) | Aston Villa | ||
| FT | Manchester City | 2-0 (2-0) | Leicester City | ||
| FT | Newcastle United | 2-1 (1-0) | Brentford | ||
| FT | Southampton | 1-1 (1-0) | Crystal Palace | ||
| FT | Liverpool | 1-0 (0-0) | Everton |
| FT | VfB Stuttgart | 3-1 (1-0) | RB Leipzig |
| FT | Derby County | 2-0 (0-0) | Preston North End |
| FT | FC Zürich | 2-2 (0-1) | Lausanne | ||
| FT | Sion | 1-2 (1-0) | Winterthur |
| FT | Feyenoord | 4-1 (2-1) | FC Groningen |
| FT | Kisvarda | 0-1 (0-0) | Paksi SE | ||
| FT | Ferencvarosi TC | 3-1 (2-0) | Ujpest |
| FT | Aris Limassol | 0-1 (0-1) | Pafos FC | ||
| FT | APOEL Nicosia | 0-1 (0-1) | AEK Larnaca |
| FT | Arda Kardzhali | 4-0 (3-0) | Cherno More Varna | ||
| FT | Botev Plovdiv | 0-0 (0-0) | Beroe | ||
| FT | PFK CSKA Sofia | 1-0 (1-0) | PFC Lokomotiv Sofia 1929 |
| FT | Stellenbosch FC | 0-0 (0-0) | Zamalek SC | ||
| FT | ASEC Mimosas | 0-1 (0-0) | RSB Berkane | ||
| FT | Al Masry SC | 2-0 (1-0) | Simba SC | ||
| FT | CS Constantine | 1-1 (1-0) | USM Alger |
| FT | Changchun Yatai | 1-1 (1-1) | Wuhan Three Towns | ||
| FT | Shanghai Shenhua | 3-1 (0-1) | Yunnan Yukun | ||
| FT | Qingdao Hainiu | 1-1 (0-1) | Dalian Yingbo | ||
| FT | Shandong Taishan | 0-3 (0-2) | Chengdu Rongcheng FC | ||
| FT | Tianjin Jinmen Tiger | 2-2 (0-1) | Beijing Guoan | ||
| FT | Shanghai Port | 2-1 (2-0) | Meizhou Hakka |
| FT | Albirex Niigata | 0-1 (0-0) | Avispa Fukuoka | ||
| FT | Cerezo Osaka | 2-1 (2-1) | Fagiano Okayama FC | ||
| FT | Gamba Osaka | 0-1 (0-1) | Machida Zelvia | ||
| FT | Kawasaki Frontale | 2-0 (0-0) | Shonan Bellmare | ||
| FT | Kyoto Sanga FC | 1-1 (0-1) | Kashiwa Reysol | ||
| FT | Nagoya Grampus | 2-0 (0-0) | Yokohama F.Marinos | ||
| FT | Sanfrecce Hiroshima | 1-0 (1-0) | Kashima Antlers | ||
| FT | Tokyo Verdy | 2-2 (1-1) | FC Tokyo | ||
| FT | Yokohama FC | 0-1 (0-0) | Vissel Kobe | ||
| FT | Urawa Red Diamonds | 2-1 (1-0) | Shimizu S-Pulse |
| FT | Chico FC | 1-4 (0-1) | Tolima |
| FT | Cienciano | 0-0 (0-0) | Atletico MG |
| FT | Once Caldas | 0-1 (0-1) | Fluminense |
| FT | Bucaramanga | 3-3 (2-1) | Colo Colo | ||
| FT | Fortaleza | 0-3 (0-1) | Racing Club |
