| FT | Columbus Crew | 2-1 (2-0) | Los Angeles FC | ||
| FT | Cruz Azul | 4-1 (1-0) | Seattle Sounders FC | ||
| FT | Tigres | 3-1 (0-1) | FC Cincinnati | ||
| FT | Monterrey | 2-2 (1-0) | Vancouver Whitecaps | ||
| FT | CF America | 4-0 (2-0) | CD Guadalajara | ||
| FT | LA Galaxy | 4-1 (2-0) | Club Sport Herediano |
| FT | Botafogo PB | 4-0 (2-0) | Concordia Atletico | ||
| Pen. | *Red Bull Bragantino | 1-1(1-1) | EC Sao Jose | ||
| FT | Vitoria | 0-2 (0-2) | Nautico | ||
| Pen. | Athletic Club | 3-3(3-3) | Gremio* | ||
| FT | Operario Ferroviario | 1-0 (1-0) | Tombense FC | ||
| FT | Capital FC | 3-1 (2-0) | Porto Velho EC | ||
| Pen. | *Maracana EC | 0-0(0-0) | Ceilandia | ||
| Pen. | Atletico GO | 1-1(1-1) | Retro FC* | ||
| Pen. | *Ceara | 2-2(2-2) | Confianca |
| FT | Cerro Porteno | 4-2 (1-1) | FBC Melgar | ||
| FT | Corinthians | 2-0 (1-0) | Barcelona SC |
| FT | Club Atletico Platense | 2-0 (0-0) | Argentino de Quilmes | ||
| FT | Huracan | 2-1 (1-1) | San Martin de Formosa |
| FT | Lille | 1-2 (1-0) | Borussia Dortmund | ||
| FT | Arsenal | 2-2 (2-1) | PSV Eindhoven | ||
| FT | Aston Villa | 3-0 (0-0) | Club Brugge | ||
| Pen. | Atletico Madrid | 1-0(1-0) | Real Madrid* |
| FT | Hull City | 2-1 (0-0) | Oxford United | ||
| FT | Leeds United | 2-0 (1-0) | Millwall | ||
| FT | Portsmouth | 1-2 (0-1) | Plymouth Argyle | ||
| FT | Watford | 1-0 (1-0) | Swansea City | ||
| FT | Stoke City | 1-0 (1-0) | Blackburn Rovers |
| FT | Cliftonville | 0-2 (0-0) | Dungannon Swifts | ||
| FT | Glentoran | 3-3 (0-2) | Glenavon |
| FT | Floriana | 0-2 (0-2) | Birkirkara |
| FT | Mjaellby | 2-0 (2-0) | Landskrona BoIS | ||
| FT | Utsiktens BK | 0-3 (0-1) | GAIS |
| FT | FK Liepaja | 0-0 (0-0) | FK Tukums 2000 | ||
| FT | SK Super Nova | 4-0 (1-0) | FS Metta/LU |
| FT | Dukla Praha | 0-0 (0-0) | Karvina |
| FT | Primorje | 2-1 (1-0) | Maribor | ||
| FT | Olimpija Ljubljana | 2-1 (1-0) | Mura |
| FT | FC Prishtina | 0-1 (0-1) | Dukagjini | ||
| FT | Malisheva | 4-1 (1-0) | Gjilani |
| FT | OFK Beograd | 1-2 (1-1) | Zeleznicar Pancevo |
| AP | Gwangju FC | AP 3-0 | Vissel Kobe | ||
| FT | Kawasaki Frontale | 4-0 (1-0) | Shanghai Shenhua |
| FT | Melbourne City FC | 0-1 (0-0) | Newcastle Jets |
