| FT | Club Sport Herediano | 2-0 (1-0) | S.V. Robinhood | ||
| FT | Philadelphia Union | 0-0 (0-0) | Pachuca | ||
| FT | Orlando City | 0-0 (0-0) | Tigres |
| Pen. | *Real Tomayapo | 0-0(0-0) | Jorge Wilstermann | ||
| FT | Universidad Catolica | 0-2 (0-0) | Coquimbo Unido | ||
| Pen. | Carabobo FC | 1-1(1-1) | Metropolitanos FC* | ||
| Pen. | *Deportivo Garcilaso | 0-0(0-0) | Asociacion Deportiva Tarma | ||
| Pen. | Tolima | 0-0(0-0) | Independiente Medellin* |
| FT | Nacional | 0-2 (0-0) | Palestino |
| FT | Instituto | 2-0 (1-0) | Huracan | ||
| FT | Barracas Central | 2-2 (2-1) | Independiente | ||
| FT | Racing Club | 0-1 (0-1) | Sarmiento | ||
| FT | Velez Sarsfield | 1-0 (0-0) | Rosario Central |
| FT | Bayern Munich | 3-0 (2-0) | Lazio | ||
| FT | Real Sociedad | 1-2 (0-1) | Paris St-Germain |
| FT | Blackburn Rovers | 1-1 (0-0) | Millwall | ||
| FT | Coventry City | 5-0 (4-0) | Rotherham United | ||
| FT | Hull City | 1-1 (1-0) | Birmingham City | ||
| FT | Leeds United | 1-0 (1-0) | Stoke City | ||
| FT | Sheffield Wednesday | 1-0 (0-0) | Plymouth Argyle | ||
| FT | Sunderland | 0-1 (0-1) | Leicester City | ||
| FT | Ipswich Town | 3-2 (0-0) | Bristol City |
| FT | Glenavon | 0-0 (0-0) | Glentoran |
| FT | Jeonbuk Hyundai Motors FC | 1-1 (1-0) | Ulsan HD FC | ||
| FT | Al Hilal | 2-0 (2-0) | Al Ittihad |
| FT | Maritimo | 1-1 (1-0) | CF Os Belenenses |
| FT | Renaissance Club Zemamra | 0-0 (0-0) | Wydad Casablanca |
| FT | Hamarkameratene | 3-1 (1-0) | Kongsvinger |
| FT | Deportivo Pasto | 1-0 (1-0) | Fortaleza FC |
| FT | LDU de Quito | 2-1 (2-1) | CSD Macara |
| FT | Tacuary | 0-2 (0-0) | Sol de America |
| FT | Deportes Copiapo | 1-3 (1-1) | Universidad de Chile |
