| FT | Aucas | 0-2 (0-0) | Tecnico Universitario | ||
| FT | Guayaquil City | 0-3 (0-0) | Manta |
| FT | Portimonense | 1-2 (1-1) | Moreirense | ||
| FT | FC Porto | 5-1 (3-0) | Farense |
| FT | Rayo Vallecano | 1-1 (0-1) | Leganes | ||
| FT | Sporting Gijon | 1-0 (0-0) | Lugo |
| FT | Real Betis | 2-1 (1-0) | Granada CF |
| FT | Fulham | 0-2 (0-2) | Burnley |
| FT | La Fiorita Montegiardino | 1-0 (0-0) | Tre Penne Galazzano |
| FT | CFR 1907 Cluj | 0-1 (0-1) | Sepsi OSK | ||
| FT | FCSB | 2-2 (1-2) | FC Academica Clinceni |
| FT | Holstein Kiel | 1-0 (1-0) | Hannover 96 | ||
| FT | Hamburger SV | 5-2 (3-1) | Nuernberg |
| FT | Botev Vratsa | 1-0 (0-0) | Montana | ||
| FT | Etar | 0-3 (0-0) | Slavia Sofia |
| FT | FC Nordsjaelland | 2-2 (0-0) | FC Koebenhavn |
| FT | IFK Norrkoeping | 2-0 (0-0) | AIK |
| FT | Academico Viseu | 1-2 (0-0) | AVS Futebol SAD |
| FT | Ural | 1-0 (1-0) | FC Rostov | ||
| FT | Spartak Moscow | 2-1 (0-1) | Khimki |
| FT | Rakow Czestochowa | 1-0 (1-0) | Piast Gliwice |
| FT | Omonia Nicosia | 1-1 (0-0) | Apollon Limassol |
| FT | Karmiotissa Pano Polemidion | 1-6 (0-2) | APOEL Nicosia |
| FT | FC Voluntari | 0-0 (0-0) | Chindia Targoviste |
| FT | Hebei FC | 1-1 (1-0) | Shanghai Shenhua | ||
| FT | Wuhan Yangtze River | 0-2 (0-1) | Beijing Guoan |
| FT | Chievo Verona | 3-0 (1-0) | Ascoli Calcio 1898 FC | ||
| FT | Cittadella | 1-1 (0-1) | Venezia | ||
| FT | Empoli | 2-1 (0-1) | Lecce | ||
| FT | LFA Reggio Calabria | 0-4 (0-2) | Frosinone | ||
| FT | LR Vicenza | 2-1 (1-1) | Reggiana | ||
| FT | Monza | 0-2 (0-0) | Brescia | ||
| FT | Pescara | 0-3 (0-0) | Salernitana | ||
| FT | Pisa | 3-2 (1-1) | Virtus Entella | ||
| FT | Pordenone Calcio | 2-0 (0-0) | Cosenza | ||
| FT | SPAL | 1-0 (0-0) | Cremonese |
| FT | Jiangxi Lushan | 1-3 (1-0) | Nantong Zhiyun FC | ||
| FT | Shenzhen Peng City | 2-1 (1-1) | Xinjiang Tianshan | ||
| FT | Nanjing City FC | 1-2 (0-1) | Kunshan FC | ||
| FT | Suzhou Dongwu | 2-1 (1-1) | Beijing Technology |
| FT | Ansan Greeners | 3-2 (1-1) | FC Anyang | ||
| FT | Busan I'Park | 4-1 (3-0) | Daejeon Hana Citizen |
| Pen. | Leon | 2-2(2-2) | Toluca* | ||
| FT | Pachuca | 4-2 (0-1) | CD Guadalajara |
| FT | Libertad | 3-1 (0-1) | 12 de Octubre | ||
| FT | Olimpia | 3-3 (1-1) | Sol de America | ||
| FT | Guairena | 0-0 (0-0) | Club River Plate |
| FT | Colon | 1-1 (1-0) | Union | ||
| FT | Huracan | 1-3 (1-1) | Independiente | ||
| FT | Lanus | 1-0 (1-0) | Talleres | ||
| FT | Newell's Old Boys | 1-1 (1-0) | Sarmiento |
| FT | Sporting Kansas City | 2-1 (0-1) | Austin FC |
| FT | FAR Rabat | 0-0 (0-0) | Wydad Casablanca | ||
| FT | RSB Berkane | 1-1 (0-0) | MAT Tetouan | ||
| FT | Raja Casablanca | 1-0 (0-0) | MAS Fes |
| FT | Audax Italiano | 0-0 (0-0) | Cobresal |
